Our CBD RSO, colloquially known as Rick Simpson Oil, is a great option for those who want the ability to easily control serving sizes. It can be mixed into food or. Other therapeutic cannabis oils tend to contain a cannabinoid called cannabidiol (CBD) and little or no THC. In addition, Rick Simpson doesn't. As a matter of fact, Rick Simpson Oil and CBD oil are derived from the same plant and provide identical medical benefits more or less, but there is a huge.
oil mg cbd simpson rick
Simpson then began growing and cultivating his own cannabis to perfect a custom oil blend, and, after health and government groups like the Canadian Cancer Society ignored his discovery, he set out to promote the medicinal effects of cannabis to others. Until , when he was ordered to stop for legal reasons, he gave away his oil — dubbed Rick Simpson Oil, or RSO — for free. Since , Simpson has lived in Europe, and, according to his website, he cannot legally enter the U.
While one of the most well-known personalities within the medical cannabis community, Simpson has also drawn some controversy and skepticism in his career. He has drawn some ire from physicians and medical professionals for his lack of scientific research or clinical trials.
Simpson still has his share of defenders who have claimed to have successfully used his blend of oil to treat cancer. On his website, Simpson states that he no longer produces or supplies his oil due to its illegality in many countries.
Simpson claims that the only way to ensure patients have his blend of oil is for patients to produce it themselves. In addition, making RSO can be dangerous — work areas need to be well ventilated with nothing sparks, open flames, etc. The process manufacturers use to produce RSO is relatively simple. The plant material is crushed and placed in a container Simpson instructs to use a bucket.
The solution is then strained into another container, washed again, then mixed. The solution is strained one final time before it is transferred to the original container. The plant material is then discarded. The solution is then filtered to remove any remaining plant matter. Next, the solution is boiled. This removes the solvent from the solution. The solvent removal process must be done in a well-ventilated area with fans blowing away the resulting fumes.
With the solvents effectively boiled off, the solution is then poured into a stainless steel pan and put into a dehydrator to remove any residual solvent. Once all the solvents have effectively been removed, the solution is cooled and placed into a syringe or capsules. After day 15, the original Chronic Strain had been consumed and administration of a new strain referred to as Hemp Oil 2 was started.
This was obtained by the family from an outside source. It was noted that administering the same dose yielded a decreased response in terms of the side effects of euphoria and appetite, and the patient suffered more nausea with this hemp oil.
There is a wide amount of variance in cannabinoid concentration amongst different strains and even in the same strain with changes in growing conditions.
The amount of each dose was increased to match the response of the blast cells that had been declining previously fig. After day 27, there was another peak blast cell count of 66, followed by a rapid decrease.
There were elevated levels of urate present in the blood with corresponding joint pain; it was established that this was caused by tumor lysis syndrome of the blast cells. On the 1st April day 41 , an infected central line with tunnel infection was noted on a blood test and the patient was admitted with a heavy antibiotic regimen of intravenous tazocin, gentamicin and vancomycin. A stronger psychosomatic response and increased fatigue were observed, so dosing was adjusted to 0.
Due to hospital restrictions, dosing was limited to twice a day. After returning home from the hospital on the 11th April day 51 , the patient suffered from intense nausea, an inability to eat and overall weakness. On the 13th April, the patient was readmitted to the SickKids Hospital and was treated for refeeding syndrome.
This was the outcome of stopping total parenteral nutrition too quickly and causing shock to the patient's body while she was being treated for the infection. The dosing regimen was intermittent until day 59, remaining at 1—2 doses per day of 0. As the blast cells began to increase and the patient's appetite increased, the dosing frequency was again increased to 3 times per day starting on day 62, and the amount administered was increased from day Dosing was maintained 3 times a day at 1.
On day 78, the patient had stomach pain in the morning and was admitted to hospital. Upon X-ray, it was noted that gastrointestinal bleeding had occurred. The patient was under a DNR order and ultimately passed away due to the bowel perforation. A prior history of pancolitis documented by CT scan in March pointed to neutropenic colitis with perforation as the cause of death.
Furthermore, prior to starting on the hemp oil treatment, the patient had been extremely ill, severely underweight and had endured numerous sessions of chemotherapy and radiation therapy in the course of 34 months. She was profoundly neutropenic… a prior history of pancolitis documented by CT scan in March was neutropenic colitis with perforation… her abdomen was distended and obviously had some signs of diffuse peritonitis.
The abdomen X-ray was in favour a perforation…she passed away at Three factors, namely frequency of dosing, amount given therapeutic dosing and the potency of the cannabis strains, were critical in determining response and disease control.
Research is needed to determine the profile and ratios of cannabinoids within the strains that exhibit antileukemic properties. These results cannot be explained by any other therapies, as the child was under palliative care and was solely on cannabinoid treatment when the response was documented by the SickKids Hospital.
This therapy has to be viewed as polytherapy, as many cannabinoids within the resinous extract have demonstrated targeted, antiproliferative, proapoptotic and antiangiogenic properties. This also needs to be explored further, as there is potential that cannabinoids might show selectivity when attacking cancer cells, thereby reducing the widespread cytotoxic effects of conventional chemotherapeutic agents. It must be noted that where our most advanced chemotherapeutic agents had failed to control the blast counts and had devastating side effects that ultimately resulted in the death of the patient, the cannabinoid therapy had no toxic side effects and only psychosomatic properties, with an increase in the patient's vitality.
The nontoxic side effects associated with cannabis may be minimized by slowly titrating the dosing regimen upwards, building up the patient's tolerance. The possibility of bypassing the psychoactive properties also exists, by administering nonpsychoactive cannabinoids such as cannabidiol that have demonstrated antiproliferative properties. Furthermore, future therapies could examine the possibility of upregulating a patient's endogenous cannabinoids to help combat leukemic cells.
It goes without saying that much more research and, even more importantly, phase clinical trials need to be implemented to determine the benefits of such therapies. Despite the nonstandardization of the medicines, the dose was readily titrated according to the biological response of the patient and produced a potentially life-saving response, namely, the drop in the leukemic blast cell count.
There has been an abundance of research exhibiting the cytotoxic effects of cannabinoids on leukemic cell lines in the form of in vitro and in vivo studies [ 1 , 2 , 3 , 4 ]. An oncology and hematology journal, Blood , has published numerous papers [ 2 ] over the years constructing the biochemical pathway to be elicited by the anticancer properties of cannabinoids.
Our goal, upon examination of this significant case study which demonstrated complete disease control and a dose response curve, is to invest effort in and to focus on research and development to advance this therapy.
An emphasis needs to be placed on determining the correct cannabinoid ratios for different types of cancer, the best method of administration, quality control and standardization of the cannabis strains and their growing conditions as well as therapeutic dosing ranges for various cancers contingent on staging and ages.
Toxicity profiles favor therapies deriving from cannabis because toxicity within the body is greatly reduced and the devastating side effects of chemoradiation i.
It is unfortunate that this therapy does come with some unwanted psychosomatic properties; however, these might be eliminated by target therapies of nonpsychoactive cannabinoids such as cannabidiol which has garnered much attention as being a potent anti-inflammatory and possible antileukemic and anticancer agent. It is acknowledged that significant research needs to be conducted to reproduce these results and that in vitro studies cannot always be reproduced in clinical trials and the human physiological microenvironment.
However, the numerous research studies and this particular clinical case are powerful enough to warrant implementing clinical trials to determine dose ranges, cannabinoid profiles and ratios, the methods of administration that produce the most efficacious therapeutic responses and the reproducibility of the results. It is tempting to speculate that, with integration of this care in a setting of full medical and laboratory support, a better outcome may indeed be achieved in the future.
National Center for Biotechnology Information , U. Journal List Case Rep Oncol v. Published online Nov Yadvinder Singh a Brampton, Ont. Chamandeep Bali b Ajax, Ont. Author information Copyright and License information Disclaimer.
Who Is Rick Simpson and What Is Rick Simpson Oil (RSO)?
Simpson originally created the so-called "Rick Simpson oil" in , of CBD and THC (both of which are present in RSO, although THC is. Learn about the story of Rick Simpson and how his cannabis oil, known as he takes just like me a dropper full of CBD mg Tincture oil. An unrefined, potent cannabis oil extracted using ethanol and named after the Canadian engineer Rick Simpson claims he cured his own skin cancer with a CBD oil contains only CBD, often from industrial hemp plants, while RSO has a.