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Voets Thomas

Mustang2000
24.06.2018

Content:

  • Voets Thomas
  • So hot it hurts - Leuven researchers uncover ion channel trio that mediates painful heat sensing
  • Manage My Suggestions
  • Thomas Voets. freshtag.me full professor. head of the Laboratory of Ion Channel Research · mail & phone. Education: Agricultural engineer (KU Leuven). Thomas Voets. photo. mail Show email. Laboratory of Ion Channel Research ( VIB-KU Leuven Center for Brain & Disease Research). O&N I Herestraat 49 - box . Ion channels are protein-based pores present in biological membranes that open and close in response to distinct chemical or physical stimuli (a process known.

    Voets Thomas

    Reintroduction of the receptors via transient transfection restored sensitivity to heat, and conversely, heat responses could also be suppressed by an inhibitor cocktail for all three TRP channels.

    The signaling was specific for the pain response to heat, as the animals responded normally to other painful stimuli such as cold, pressure or pinpricks, and their overall thermal preference was not affected. This triple knock out mouse represents the first demonstration in mammals of elimination of the pain response to a physical stimulus at the level of the signal-transducing ion channel.

    It ensures we avoid dangerous heat, even if one or even two heat sensors are compromised. In such conditions, the three heat-activated TRP channels can get deregulated, signaling painful heat even when there is no risk of burning. By developing new drugs that specifically temper the activity of these molecular heat detectors, we hope to be able to provide effective and safe means to treat chronic pain in patients.

    The realizations of VIB researchers can form the basis of new therapies, but the development path still takes years. This can raise a lot of questions.

    That is why we ask you to please refer questions in your report or article to the email address that VIB makes available for this purpose: Everyone can submit questions concerning this and other medically-oriented research directly to VIB via this address.

    Page Content Zone 2. Thomas Voets Fluorescent nerve endings in the skin. This chemical selectively activates a third TRP channel, which prompted the scientists to go one step further and generate a triple knockout.

    Mice with all three TRP channels eliminated showed a complete loss of heat-induced pain responses. Reintroduction of the receptors via transient transfection restored sensitivity to heat, and conversely, heat responses could also be suppressed by an inhibitor cocktail for all three TRP channels.

    The signaling was specific for the pain response to heat, as the animals responded normally to other painful stimuli such as cold, pressure or pinpricks, and their overall thermal preference was not affected.

    This triple knock out mouse represents the first demonstration in mammals of elimination of the pain response to a physical stimulus at the level of the signal-transducing ion channel. It ensures we avoid dangerous heat, even if one or even two heat sensors are compromised. In a next step, the researchers want to investigate how these channels can be targeted to treat chronic pain. In such conditions, the three heat-activated TRP channels can get deregulated, signaling painful heat even when there is no risk of burning.

    By developing new drugs that specifically temper the activity of these molecular heat detectors, we hope to be able to provide effective and safe means to treat chronic pain in patients. Questions from patients A breakthrough in research is not the same as a breakthrough in medicine. The realizations of VIB researchers can form the basis of new therapies, but the development path still takes years.

    So hot it hurts - Leuven researchers uncover ion channel trio that mediates painful heat sensing

    Thomas Voets of KU Leuven, Leuven (ku leuven) with expertise in: Physiology. Read publications, and contact Thomas Voets on ResearchGate, the. View the profiles of professionals named Thomas Voets on LinkedIn. There are 16 professionals named Thomas Voets, who use LinkedIn to exchange. Thomas Voets. KU Leuven Department of Cellular and Molecular Medicine and VIB Center for Brain & Disease Research. Verified email at freshtag.me

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    Comments

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    Thomas Voets of KU Leuven, Leuven (ku leuven) with expertise in: Physiology. Read publications, and contact Thomas Voets on ResearchGate, the.

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    View the profiles of professionals named Thomas Voets on LinkedIn. There are 16 professionals named Thomas Voets, who use LinkedIn to exchange.

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    Thomas Voets. KU Leuven Department of Cellular and Molecular Medicine and VIB Center for Brain & Disease Research. Verified email at freshtag.me

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    View the profiles of people named Thomas Voets. Join Facebook to connect with Thomas Voets and others you may know. Facebook gives people the power to.

    wasd000

    Mar 14, Thomas Voets (VIB - KU Leuven) and prof. Joris Vriens (KU Leuven) used genetic knockout models to pinpoint which molecular partners are.

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