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AEROGROW INTL INC(AERO )

Hanuš Lumír

Bumoc82
02.12.2018

Content:

  • Hanuš Lumír
  • Cannabis Medicine and Patients: Who is Satisfied? | L. Hanuš, Cannafest 2017
  • Supplementary files
  • Lumír Ondřej Hanuš (Hebrew: לומיר הנוש ) is a Czech analytic chemist and leading authority in the field of cannabis research. In , he and William Anthony. Yuval Zolotov: Professor Lumir Hanuš, thank you very much for granting us this interview. After more than 45 years of being engaged with cannabinoid research, . Lumir Hanus with expertise in: Analytical Chemistry. Read publications, 1 answers, and contact Lumir Hanus on ResearchGate, the professional network for.

    Hanuš Lumír

    Zero-filling and suitable apodization functions were applied to enhance the spectral resolution. The spectra were analyzed by using Aurelia 2. The one-dimensional proton spectra and the 2D-correlated spectroscopy and total-correlation spectroscopy spectra of natural and synthetic noladin were compared and found to be identical under the acquisition conditions.

    The chemically identical alkene methine protons 6, 7, 9, 10, 12, 13, 15, and 16 are overlapped, as are the methylene protons 8, 11, and 14 that have double bonds at both sides.

    The alkane protons 2 and 3 are resolved only in the carbon dimension. Female Sabra mice Harlan, Jerusalem, Israel were injected i. Each mouse was observed 10 min later in four consecutive assays as described Thus, the testing started: The results are presented in Fig.

    Performance of mice injected with synthetic noladin ether on pharmacological tests for cannabinoid effects. Noladin ether was injected 10 min before the start of testing. For further details see Materials and Methods. Each treatment group consisted of six mice.

    Control and synthetic noladin ether-treated mice were compared with t tests for independent samples. The purity of the isolated material 0. Initial indications for the structure of the endocannabinoids were noted from MS and NMR spectroscopy data. The NMR spectrum indicated the presence of nonconjugated double bonds with an 8: These findings and other MS and NMR data suggested that the endocannabinoid noladin ether could be the ether of glycerol with arachidonyl alcohol.

    Both anandamide, an amide, and 2-AG, an ester, are prone to facile hydrolytic and enzymatic hydrolysis. To prepare a more stable entity related to 2-AG, we had synthesized noladin ether already see Fig. Independently, Sugiura et al. The availability of synthetic noladin ether made possible a direct comparison with the natural product. Noladin ether inhibited the specific binding of [ 3 H]HU 11 to the CB 1 receptor from rat brain synaptosomal membranes in a manner typical of competitive ligands Fig.

    The inhibition constant K i value for noladin ether was Synthetic noladin ether was examined for behavioral effects by using tests frequently used for cannabinoid evaluation Hypothermia, antinociception hot-plate latency and rate of defecation in the open field, a measure of intestinal motility, were assessed also.

    The results presented in Fig. They are present in mammals, birds, plants, protozoa, and bacteria. They are particularly wide spread in marine animals.

    They have been found in chicken egg yolk, human bone marrow and milk, pig spleen, and intestinal fat and liver in rat. For a recent review, see ref. Some 1-alkyl glyceryl ether-based phospholipids such as platelet-activating factor, for example, have many physiological and pathological attributes 21 , and related synthetic ether phospholipids have antineoplastic activity and are investigated widely in oncology 22 — 24 and against visceral leishmaniasis Reduced levels of 1-alkyl glyceryl ethers have been noted in some peroxisomal diseases such as Zellweger syndrome Surprisingly, very few 2-alkyl glycerol ethers are known as natural products and noladin ether seems to be, to our knowledge, the first such example of a long-chain fatty alcohol moiety forming an ether at the C-2 position of glycerol.

    Anandamide and 2-AG do not have the same pharmacological profile 5 — Humans , Gallbladder , and Cholelithiasis. Capillary gas chromatography of natural substances from Cannabis sativa L. Cannabinol and cannabinolic acid--artefacts more. Correlation of spatial distinction with cannabinoid receptor binding. Heterocycles 39 2 , more.

    Our experience with identification and separation of compounds from marijuana Cannabis sativa L. Content of cannabinoids in dried roots more. Chromatographic study of the effect of higher temperatures on changes in the content of some cannabinoid substances in Cannabis samples more.

    The effect of deltatetrahydrocannabinol deltaTHC on the release of nonesterified fatty acids in various brain structures more. The effect of soil fertilization on the formation and the amount of cannabinoid substances in Cannabis sativa L. Biogenesis of cannabinoid substances in the plant more. Chemistry , Cannabinoids , and Cannabis. Our experience with the identification and separation of compounds from marijuana Cannabis sativa L.

    European Journal of Organic Chemistry more. Conception and some results of cannabis research at the Medical Faculty in Olomouc. The present state of knowledge in the chemistry of substances of Cannabis sativa L. Metabolites of cannabinoid substances. Isolation of two new cannabinoid acids from Cannabis sativa L.

    Identification of cannabinoidic acids by thin-layer chromatography of their methylesters. Endogenous and synthetic cannabinoids: CNS Drug Reviews 2 4 , more. Pharmaceutical Chemistry Journal 42 12 , more. Binding and functional studies with the peripheral and neuronal cannabinoid receptors. Regulatory Peptides 54, more.

    Lipids of wild edible mushrooms of the genus Boletus. Journal of Food Lipids 15 3 , more. Sinsemilla and its cultivation in climatic conditions of Czechoslovakia - a potential danger of abuse of marihuana of high quality. Substances of cannabinoid type. Production of deltatetrahydrocannabinol from hemp cultivated in climatic conditions of Czechoslovakia.

    Isolation of cannabidiolic acid from Turkish variety of cannabis cultivated for fibre. Analysis of resinous material present on an alabaster lid excavated from Nabatean Moa in the Arava Valley.

    Arabian Archaeology and Epigraphy 24, more. An alabaster lid with a resinous accretion burnt or stuck next to the handle and on the base was uncovered in the Nabataean rest stop in Moyat Aawad Moa in the Arava valley in Israel. The analysis of this resin sample utilising GC-MS It has been shown to cause numerous physiological effects of therapeutic importance. We have reported that CBD derivatives in both enantiomeric series are of pharmaceutical interest. The binding of these compounds to the CB 1 and CB 2 cannabinoid receptors are compared.

    Some of these compounds also bind weakly to the CB 2 receptor. The article was received on 08 Nov , accepted on 25 Jan and first published on 16 Feb If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center.

    Go to our Instructions for using Copyright Clearance Center page for details. Authors contributing to RSC publications journal articles, books or book chapters do not need to formally request permission to reproduce material contained in this article provided that the correct acknowledgement is given with the reproduced material. If the material has been adapted instead of reproduced from the original RSC publication "Reproduced from" can be substituted with "Adapted from". In all cases the Ref.

    Cannabis Medicine and Patients: Who is Satisfied? | L. Hanuš, Cannafest 2017

    Prof. Lumir. Professor Lumír Ondřej Hanuš is a world-renowned analytical chemist and a leading figure in the field of cannabis research. Read more. L Hanuš, S Abu-Lafi, E Fride, A Breuer, Z Vogel, DE Shalev, I Kustanovich, Proceedings of the National Academy of Sciences 98 (7), , Biography. Lumír Ondřej Hanuš obtained his M.S. in analytical chemistry, Ph.D. in analytical chemistry and associate professor in organic chemistry from.

    Supplementary files



    Comments

    netbank

    Prof. Lumir. Professor Lumír Ondřej Hanuš is a world-renowned analytical chemist and a leading figure in the field of cannabis research. Read more.

    jarikk

    L Hanuš, S Abu-Lafi, E Fride, A Breuer, Z Vogel, DE Shalev, I Kustanovich, Proceedings of the National Academy of Sciences 98 (7), ,

    glebasya16

    Biography. Lumír Ondřej Hanuš obtained his M.S. in analytical chemistry, Ph.D. in analytical chemistry and associate professor in organic chemistry from.

    stito

    Lumír Ondřej Hanuš. Illustration of cannabis (Courtesy). October 15, , pm. Israeli lab set up to give clinical validation to cannabis research · Lumis Lab.

    tvinktvink111

    ​Lumír Ondřej Hanuš obtained his M.S. in analytical chemistry (), Ph.D. in analytical chemistry () and associate professor in organic chemistry ().

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