Pure and Organic CBD & and Hemp Products

Effective medicine provided by mother nature

  • Powerful relaxant

  • Strong painkiller

  • Stress reduction
  • Energy booster

Why CBD?

More and more renowned scientists worldwide publish their researches on the favorable impact of CBD on the human body. Not only does this natural compound deal with physical symptoms, but also it helps with emotional disorders. Distinctly positive results with no side effects make CBD products nothing but a phenomenal success.

This organic product helps cope with:

  • Tight muscles
  • Joint pain
  • Stress and anxiety
  • Depression
  • Sleep disorder

Range of Products

We have created a range of products so you can pick the most convenient ones depending on your needs and likes.

CBD Capsules Morning/Day/Night:

CBD Capsules

These capsules increase the energy level as you fight stress and sleep disorder. Only 1-2 capsules every day with your supplements will help you address fatigue and anxiety and improve your overall state of health.

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CBD Tincture

CBD Tincture

No more muscle tension, joints inflammation and backache with this easy-to-use dropper. Combined with coconut oil, CBD Tincture purifies the body and relieves pain. And the bottle is of such a convenient size that you can always take it with you.

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Pure CBD Freeze

Pure CBD Freeze

Even the most excruciating pain can be dealt with the help of this effective natural CBD-freeze. Once applied on the skin, this product will localize the pain without ever getting into the bloodstream.

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Pure CBD Lotion

Pure CBD Lotion

This lotion offers you multiple advantages. First, it moisturizes the skin to make elastic. And second, it takes care of the inflammation and pain. Coconut oil and Shia butter is extremely beneficial for the health and beauty of your skin.

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Are there side effects of using CBD on the skin?

Kush 3 – CBD

chabs1
23.06.2018

Content:

  • Kush 3 – CBD
  • Medical Strain
  • Where to Buy CBD Kush
  • CBD Kush from Dutch Passion was produced in cooperation with the CBD Crew. CBD Kush is a CBD rich variety with an approximate ratio of THC:CBD. Find information about the CBD Kush cannabis strain including reviews from other users, its most CBD Kush Flavors. 1. Woody. 2. Earthy. 3. Spicy/Herbal. Find information about the Critical Kush cannabis strain including reviews from a staggeringly high THC content with a moderate dose of CBD, making this strain a Critical Kush Flavors. 1. Earthy. 2. Woody. 3. Flowery.

    Kush 3 – CBD

    Therefore, more clinical research is warranted on CBD action on hepatic enzymes, drug transporters, and interactions with other drugs and to see if this mainly leads to positive or negative effects, for example, reducing the needed clobazam doses in epilepsy and therefore clobazam's side effects.

    This review also illustrates that some important toxicological parameters are yet to be studied, for example, if CBD has an effect on hormones. Additionally, more clinical trials with a greater number of participants and longer chronic CBD administration are still lacking. The most prominent of those is cannabidiol CBD. For instance, it is anxiolytic, anti-inflammatory, antiemetic, and antipsychotic. Moreover, neuroprotective properties have been shown.

    At lower doses, it has physiological effects that promote and maintain health, including antioxidative, anti-inflammatory, and neuroprotection effects. For instance, CBD is more effective than vitamin C and E as a neuroprotective antioxidant and can ameliorate skin conditions such as acne. The comprehensive review of original studies by Bergamaschi et al.

    Moreover, psychological and psychomotor functions are not adversely affected. The same holds true for gastrointestinal transit, food intake, and absence of toxicity for nontransformed cells.

    Nonetheless, some side effects have been reported for CBD, but mainly in vitro or in animal studies. They include alterations of cell viability, reduced fertilization capacity, and inhibition of hepatic drug metabolism and drug transporters e. In these studies, a large enough number of subjects have to be enrolled to analyze long-term safety aspects and CBD possible interactions with other substances. This review will build on the clinical studies mentioned by Bergamaschi et al.

    Before we discuss relevant animal research on CBD possible effects on various parameters, several important differences between route of administration and pharmacokinetics between human and animal studies have to be mentioned.

    First, CBD has been studied in humans using oral administration or inhalation. Administration in rodents often occures either via intraperitoneal injection or via the oral route. Second, the plasma levels reached via oral administration in rodents and humans can differ. Both these observations can lead to differing active blood concentrations of CBD. In addition, it is possible that CBD targets differ between humans and animals. Therefore, the same blood concentration might still lead to different effects.

    Even if the targets, to which CBD binds, are the same in both studied animals and humans, for example, the affinity or duration of CBD binding to its targets might differ and consequently alter its effects. The following study, which showed a positive effect of CBD on obsessive compulsive behavior in mice and reported no side effects, exemplifies the existing pharmacokinetic differences.

    This higher bioavailability, in turn, can cause larger CBD effects. This calculation was performed assuming the pharmacokinetics of a hydrophilic compound, for simplicity's sake.

    We are aware that the actual levels of the lipophilic CBD will vary. A second caveat of preclinical studies is that supraphysiological concentrations of compounds are often used. This means that the observed effects, for instance, are not caused by a specific binding of CBD to one of its receptors but are due to unspecific binding following the high compound concentration, which can inactivate the receptor or transporter.

    The following example and calculations will demonstrate this. This can have several implications because various anticancer drugs also bind to these membrane-bound, energy-dependent efflux transporters. The rationale behind suggesting these concentrations is that studies summarized by Bih et al. It also seems warranted to assume that the mean plasma concentration exerts the total of observed CBD effects, compared to using peak plasma levels, which only prevail for a short amount of time.

    This paragraph describes CBD interaction with general drug -metabolizing enzymes, such as those belonging to the cytochrome P family. This might have an effect for coadministration of CBD with other drugs. Various drugs such as ketoconazol, itraconazol, ritonavir, and clarithromycin inhibit this enzyme.

    It has to be pointed out though, that the in vitro studies used supraphysiological CBD concentrations. Studies in mice have shown that CBD inactivates cytochrome P isozymes in the short term, but can induce them after repeated administration.

    This is similar to their induction by phenobarbital, thereby implying the 2b subfamily of isozymes. Hexobarbital is a CYP2C19 substrate, which is an enzyme that can be inhibited by CBD and can consequently increase hexobarbital availability in the organism. Recorcinol was also found to be involved in CYP induction.

    CYP1A1 can be found in the intestine and CBD-induced higher activity could therefore prevent absorption of cancerogenic substances into the bloodstream and thereby help to protect DNA. This means that they do not reduce CBD transport to the brain. The same goes for gefitinib inhibition of Bcrp. These proteins are also expressed at the blood—brain barrier, where they can pump out drugs such as risperidone.

    This is hypothesized to be a cause of treatment resistance. Nicardipine was used as the BCRP substrate in the in vitro studies, where the Jar cell line showed the largest increase in BCRP expression correlating with the highest level of transport.

    The ex vivo study used the antidiabetic drug and BCRP substrate glyburide. In this study, a dose—response curve should be established in male and female subjects CBD absorption was shown to be higher in women because the concentrations used here are usually not reached by oral or inhaled CBD administration.

    Nonetheless, CBD could accumulate in organs physiologically restricted via a blood barrier. Some studies indicate that under certain circumstances, CBD acute anxiolytic effects in rats were reversed after repeated day administration of CBD. Nonetheless, the behavioral tests for OBX-induced hyperactivity and anhedonia related to depression and open field test for anxiety in the CBD-treated OBX animals showed an improved emotional response.

    Using microdialysis, the researchers could also show elevated 5-HT and glutamate levels in the prefrontal cortex of OBX animals only. This area was previously described to be involved in maladaptive behavioral regulation in depressed patients and is a feature of the OBX animal model of depression.

    The fact that serotonin levels were only elevated in the OBX mice is similar to CBD differential action under physiological and pathological conditions.

    A similar effect was previously described in anxiety experiments, where CBD proved to be only anxiolytic in subjects where stress had been induced before CBD administration.

    Elevated glutamate levels have been proposed to be responsible for ketamine's fast antidepressant function and its dysregulation has been described in OBX mice and depressed patients. Chronic CBD treatment did not elicit behavioral changes in the nonoperated mice.

    No adverse effects were reported in this study. Various studies on CBD and psychosis have been conducted. The two higher CBD doses had beneficial effects comparable to the atypical antipsychotic drug clozapine and also attenuated the MK effects on the three markers mentioned above. The publication did not record any side effects. One of the theories trying to explain the etiology of bipolar disorder BD is that oxidative stress is crucial in its development.

    Whereas CBD did not have an effect on locomotion, it did increase brain-derived neurotrophic factor BDNF levels and could protect against amphetamine-induced oxidative damage in proteins of the hippocampus and striatum.

    No adverse effects were recorded in this study. Another model for BD and schizophrenia is PPI of the startle reflex both in humans and animals, which is disrupted in these diseases. CBD, which is nonhedonic, can reduce heroin-seeking behavior after, for example, cue-induced reinstatement.

    In addition, the described study was able to replicate previous findings showing no CBD side effects on locomotor behavior. There are various mechanisms underlying neuroprotection, for example, energy metabolism whose alteration has been implied in several psychiatric disorders and proper mitochondrial functioning. A study comparing acute and chronic CBD administration in rats suggests an additional mechanism of CBD neuroprotection: Mitochondrial activity was measured in the striatum, hippocampus, and the prefrontal cortex.

    Since the mitochondrial complexes I and II have been implied in various neurodegenerative diseases and also altered ROS reactive oxygen species levels, which have also been shown to be altered by CBD, this might be an additional mechanism of CBD-mediated neuroprotection.

    In healthy cells, this can be interpreted as a way to protect against the higher ROS levels resulting from more mitochondrial activity. Another publication studied the difference of acute and chronic administration of two doses of CBD in nonstressed mice on anxiety.

    Already an acute i. Fifteen days of repeated i. However, the higher dose caused a decrease in neurogenesis and cell proliferation, indicating dissociation of behavioral and proliferative effects of chronic CBD treatment. The study does not mention adverse effects. Numerous studies show the CBD immunomodulatory role in various diseases such as multiple sclerosis, arthritis, and diabetes.

    These animal and human ex vivo studies have been reviewed extensively elsewhere, but studies with pure CBD are still lacking. It would be especially interesting to study when CBD is proinflammatory and under which circumstances it is anti-inflammatory and whether this leads to side effects Burstein, Table 1 shows a summary of its anti-inflammatory actions; McAllister et al. In case of Alzheimer's disease AD , studies in mice and rats showed reduced amyloid beta neuroinflammation linked to reduced interleukin [IL]-6 and microglial activation after CBD treatment.

    This led to amelioration of learning effects in a pharmacological model of AD. The chronic study we want to describe in more detail here used a transgenic mouse model of AD, where 2. CBD was able to prevent the development of a social recognition deficit in the AD transgenic mice. Using statistical analysis by analysis of variance, this was shown to be only a trend.

    This might have been caused by the high variation in the transgenic mouse group, though. This was probably due to already elevated cholesterol in the transgenic mice. The study observed no side effects. After CBD treatment was stopped, observation continued until the mice were 24 weeks old. CBD increased IL levels, which is thought to act as an anti-inflammatory cytokine in this context.

    After inducing arthritis in rats using Freund's adjuvant, various CBD doses 0. CBD reduced joint swelling, immune cell infiltration. CBD was shown to be able to influence migratory behavior in cancer, which is also an important aspect of embryogenesis. Helix-loop-helix Id proteins play a role in embryogenesis and normal development via regulation of cell differentiation. High Id1-levels were also found in breast, prostate, brain, and head and neck tumor cells, which were highly aggressive.

    In contrast, Id1 expression was low in noninvasive tumor cells. Id1 seems to influence the tumor cell phenotype by regulation of invasion, epithelial to mesenchymal transition, angiogenesis, and cell proliferation. There only seems to exist one study that could not show an adverse CBD effect on embryogenesis.

    An in vitro study could show that the development of two-cell embryos was not arrested at CBD concentrations of 6. Various studies have been performed to study CBD anticancer effects. CBD every 3 days for a total of 28 weeks, almost completely reduced the development of metastatic nodules caused by injection of human lung carcinoma cells A in nude mice.

    The typical side effects of traditional anticancer medication, emesis, and collateral toxicity were not described in these studies.

    Consequently, CBD could be an alternative to other MMP1 inhibitors such as marimastat and prinomastat, which have shown disappointing clinical results due to these drugs' adverse muscoskeletal effects.

    Two studies showed in various cell lines and in tumor-bearing mice that CBD was able to reduce tumor metastasis.

    CBD downregulated Id1 at promoter level and reduced tumor aggressiveness. Moreover, to carry out these experiments, animals are often immunologically compromised, to avoid immunogenic reactions as a result to implantation of human cells into the animals, which in turn can also affect the results.

    Another approach was chosen by Aviello et al. After 3 months, the number of aberrant crypt foci, polyps, and tumors was analyzed. The high CBD concentration led to a significant decrease in polyps and a return to near-normal levels of phosphorylated Akt elevation caused by the carcinogen.

    Animal studies summarized by Bergamaschi et al. Chronic administration 14 days, 2. This effect could be inhibited by coadministration of a CB2R antagonist. The positive effects of CBD on hyperglycemia seem to be mainly mediated via CBD anti-inflammatory and antioxidant effects. In addition, treatment increased adiponectin and liver glycogen concentrations. CBD showed inhibition of testosterone oxidation in the liver. Motor function was also tested on a rotarod, which was also not affected by CBD administration.

    GoldDrop Gold Standard mg Cartridges. GoldDrop Black Standard mg Cartridge. Beboe Pastilles Sativa Blend. Dark Chocolate with Raspberries. Milk Chocolate with Toffee Pieces. Dark Chocolate with Crystalized Ginger. Altai Salted Almond Pips. Kush Queen Love Bath Bomb. Kush Queen Relax Bath Bomb. Kush Queen Awaken Bath Bomb. Legion of Bloom Battery. By clicking the Agree button below, you're confirming that you're at least 21 years or older.

    Kona Gold is an excellent strain for patients who never medicate with cannabis or desire mild effects from their medication. This strain is a mildly potent indica that does a wonderful job of stimulating hunger. Kryptonite is an indica dominant hybrid that patients rely on to regain their appetite. This combination makes LA Chocolat a good go-to strain for pa LA Confidential is a highly potent, pure indica strain with a robust cannabinoid profile.

    This rare strain contains all 6 key cannabinoids, which is why it can be recommended for a number of different Lamb's Bread is a Jamaican-derived cannabis plant that is sometimes called "Lamb's Breath. Larry OG is an indica dominant hybrid that patients can medicate with to spur their appetite. The moderate levels of THC allow infrequent cannabis users to medicate with this strain without having to Lavender is an indica-dominant hybrid and is famous for its relaxing properties.

    Patients who want to fight off their stress and mentally escape find Lavender to be the perfect medication. Experienced patients looking for an invigorating strain should be more than happy with the effects Lemon Haze provides.

    The combination of Lemon Skunk and Silver Haze results in a strain that is high Lemon Kush is a cerebral strain thanks to its substantial THC and CBC content, but its effects on the rest of the body are what make this an important medicinal strain. Glaucoma patients will be able Patients who medicate with Lemon Tree tend to describe this strain as "euphoric. The G genetics are what makes this strain so soothing, and the Chemdawg genetics breathe some energy Lucinda is an upbeat, sativa dominant strain that is useful for relieving symptoms of anxiety and depression.

    Even though Lucinda isn't considered a "heavy hitter", it can still cause anxiety and para There is a reason why so many patients consider Mango to be a "heavy indica. Mango Kush is an indica-dominant strain that combines the flavor of Mango with the indica effects of Hindu Kush. Known for stimulating hunger, patients will have a hard time resisting the munchies aft Maple Wreck is an effective strain for those seeking pain-relief.

    For a pure sativa, this strain has unusually high CBN Looking for a pain-relieving, energy-boosting, and euphoric medical cannabis strain?

    Maui Kush has you covered. This strain is sure to have patients feeling up and active after medicating, not only be Medicine Man, also known as White Rhino, is famous for its high THC and CBD percentage, which explains why it is so highly regarded amongst the medical marijuana community.

    For patients who need an an Mendocino Purps is a pure indica that is known to make patients' eyes feel heavy. The indica genetics, combined with high levels of CBN and CBG effectively reduce ocular pressure for glaucoma patients Monster Cookies, a combination of Granddaddy Purple and Girl Scout Cookies, is an indica-dominant hybrid that helps patients regain their appetite.

    Due to its above average potency, high CBN levels, a Moonshine Haze is an interesting strain because it has what would be considered an "empty" cannabinoid profile. Nice has all of the effects one would typically expect from an indica, but with a lower-than-average THC percentage.

    Beginner patients who want a strain to promote sleep, lower intraocular pressur Nero de Diablo is a highly potent sativa strain that only experienced patients should medicate with. Nuken is a low-potency indica strain that can be used to stimulate appetite and improve mood. This Canadian strain allows patients to medicate without becoming overwhelmed by egregious amounts of THC, NYC Diesel is one of the best strains for patients who need anxiety relief without having to worry about paranoia creeping in.

    Because the effects are clear with no signs of lethargy, NYC Diesel is ve Oaxacan Querkle is a hybrid strain with a robust and balanced cannabinoid profile that can be used to treat a wide variety of ailments. OG Kush is one of the most prevalent strains on the market today. This indica-dominant hybrid leaves patients feeling "trance-like" - both in the mind, and in the body, due to the absence of THCV. Ogre is famous for its extremely heavy effects. Patients suffering from debilitating ailments report falling asleep soundly after medicating with this strain.

    This strain's intense potency and high CB Papaya is an indica-dominant hybrid that medical marijuana patients usually use to treat their lack of appetite. The combination of Citral 13 and Ice 2 gives this strain its characteristically heavy Due to its indica dominant genetics and high CBN Pineapple puts the mind and the body at ea Pineapple Express is the now famous sativa-dominant hybrid that leaves patients feeling energized and clear-headed.

    The combination of Trainwreck and Hawaiian makes this strain highly potent, so only Pineapple Kush is a combination of Pineapple and Master Kush. This highly potent, indica-dominant hybrid is known to make patients feel uplifted due to its very high CBC levels - great for patients wh Platinum Cookies is another phenotype of the classic Girl Scout Cookies strain.

    This strain is best known for its above average THC percentage which works to help distract patients from debilitating c Platinum Purple Kush is highly potent, and only experienced cannabis patients should medicate with this strain. Experienced patients who have built up a THC tolerance can medicate with Platinum Romulan to treat a number of different ailments, thanks to this strain's robust cannabinoid profile.

    Purple Cadillac is an indica strain that even beginner patients can medicate with thanks to its subtle effects and low THC percentage. Patients who medicate with this strain oftentimes report that the Most websites claim that this strain is a cross between BC Sweet Tooth and Purple Cream is a very powerful medication that should be reserved for only experienced patients. This pure indica has heavy-hitting effects, which is why PotBot recommends that patients save this str Patients who are looking for a fast-acting, low potency strain to help treat depression and PTSD will be very happy with Purple Gorilla.

    Purple Gorilla has very high levels of CBC, which is why patien Purple Ribbon is an indica dominant hybrid that can be used by wasting patients to stimulate appetite. Patients who medicate with Purple Wreck do so, typically in low dosages, for quick pain relief and a slight energy boost.

    Lethargy is a common symptom after medicating with Purple Trainwreck, so patie Purple Urkle is a low-potency indica strain that helps patients reduce ocular pressure, stimulate appetite, and fall asleep. This Star Trek-themed strain is a highly popular indica-dominant hybrid that patients use for its classic "heavy indica" effects. Patients who medicate with Romulan usually do so to feel hungry and to There is a good chance that patients will be tempted to buy Royal Purple Kush based off of looks alone, but this indica-dominant hybrid has a wonderfully balanced cannabinoid profile that helps improv SFV OG is a tricky strain to describe for a couple of different reasons.

    For one, it is highly debated whether this OG Kush phenotype is actually sativa-dominant or indica-dominant. Some claim to feel The descendant of Skunk 1 and White Widow, Shark Shock is a potent strain with typical indica effects. Patients who medicate with this strain can expect an elevation in mood, due to the high THC and C Sherbert is a useful medicinal strain for anyone who desires fast-acting effects without having to worry about being overwhelmed by the potency.

    Unlike most recreational-facing strains, this indica-do Since it was first created in the s, Skunk 1 has become famous throughout the world for parenting the group of Skunk crosses.

    This hybrid is known for its one-two punch of eliminating stress and Skunk Haze is a sativa dominant strain that typically has a 1: Because of this, Skunk Haze is a useful medication for patients who tend to get anxious or paranoid from high THC alte Sky Chem, which is a combination of Blueberry, Chemdawg, and Skywalker OG, is one of the best strains available for improving mood.

    This indica-dominant hybrid is special because not only does it cont Some patients prefer a strain with powerful, mentally-stimulating effects, while others prefer a strain that affects only the body. Patients who fall into the latter category will appreciate Sky Hash Skywalker is known for its potent and heavy effects, and as a result, beginner patients are advised to choose a lower THC alternative.

    Considered by many to be a quintessential indica, patients can ex Sonoma Coma is a potent sativa-dominant hybrid that helps patients suffering from depression and PTSD forget about their troubles. Sour Diesel is a massively-popular sativa strain that patients revere for its ability to stimulate the mind without slowing down the body.

    This strain energizes patients with its sativa genetics, and Space Queen is a potent hybrid that combines Romulan with Cinderella 99 to create a strain that makes patients feel euphoric and happy.

    Medical Strain

    High CBD and low THC strains are great for people seeking It is an indica- dominant strain with high CBD and a lower THC . 3 Dec Special Kush 1, created by Royal Queen Seeds, is an indica-dominant cross that its space, but given enough space, like outdoors, it can grow to over 3 m tall. CBD's reported benefits include relief from anxiety, joint pain, PTSD, menstrual cramps, insomnia, By Jenni Avins April 3, one could just go ahead and smoke a high-CBD strain of marijuana the old-fashioned way.

    Where to Buy CBD Kush



    Comments

    paparxidis10

    High CBD and low THC strains are great for people seeking It is an indica- dominant strain with high CBD and a lower THC . 3 Dec

    kolek99

    Special Kush 1, created by Royal Queen Seeds, is an indica-dominant cross that its space, but given enough space, like outdoors, it can grow to over 3 m tall.

    praporuga

    CBD's reported benefits include relief from anxiety, joint pain, PTSD, menstrual cramps, insomnia, By Jenni Avins April 3, one could just go ahead and smoke a high-CBD strain of marijuana the old-fashioned way.

    stalker232

    Yet cannabis also contains a cannabinoid known as CBD (or profile of the drug has changed drastically over the past three decades.

    mococa

    An indica-dominant strain with a balanced THC-to-CBD ratio. Available in. Strength A THC-dominant indica strain with little-to-no CBD. Available in. Strength.

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